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Moderate (80-150 mg)
This is the most common dose for an MDMA experience and the dose used in clinical trials. In this range, users report the typical MDMA-associated sensations: euphoria, increased energy, empathy, etc. In this range, many people practice “re-upping,” which involves taking an initial 80-120mg dose, followed by an additional 40-80mg later on. This is the practice for MAPS’ clinical trials. Common effects may include:
- Strong euphoria
- Therapeutic introspection
- Heightened self-esteem
- Openness and self-forgiveness
- Heightened empathy and sociability
- Increased energy
- Enhanced tactile, visual and auditory senses
- Dry mouth
- Jaw clenching/grinding
- Insomnia
- Possible next-day comedown effects, e.g. fatigue, depression (can also be felt over the next seven days)
EXPERIENCES OF MDMA (Ecstasy Pills)
Many factors contribute to the MDMA experience, including dose, mindset, and setting. While there’s no way to predict exactly what will happen, following the Six S’s can help ensure you’ll have a positive experience with minimal negative effects.
What to expect
For most clinical trials, researchers administer doses between 80 and 150mg of MDMA. At this dose level, the onset of effects occurs approximately 20 to 60 minutes after taking the drug, and the characteristic effects (euphoria, increased empathy, and energy, enhanced sensations) typically last for three to five hours.
The high is usually characterized by a relaxed, euphoric state, including emotional openness, reduction of negative thoughts, and a decrease in inhibitions. MDMA can make users feel like all is well in the world, and connecting with others becomes easy. Bodily sensations and touch become enhanced, and sounds and colors can appear more intense.
These effects themselves could be important to the drug’s healing potential by offering users greater access to their inner selves. But researchers also believe that the openness MDMA fosters could speed up the bond between patient and therapist, creating a setting conducive to healing.
How is MDMA used?
MDMA is most often available in tablet or capsule form and is usually ingested by mouth. Ecstasy traffickers consistently use brand names, colors and logos as marketing tools and to distinguish their product from that of competitors. The logos may be produced to coincide with holidays or special events. Among the more popular logos are butterflies, lightning bolts, and four-leaf clovers.
How is MDMA used in medicine?
The DEA considers MDMA an illegal schedule I drug with no recognized medical uses.
Researchers are looking at MDMA use as a possible treatment for:
- post-traumatic stress disorder (PTSD)
- anxiety in terminally ill patients
- social anxiety in autistic adults



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